Comparison of two doses of intravenous Dexmedetomidine 0.6mcg/kg and 1mcg/kg given prior to induction in attenuation of hemodynamic stress response of laryngoscopy and endotracheal intubation
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 8, Issue 1
Abstract
Background: Laryngoscopy and endotracheal intubation is accompanied by sympathomimetic stimulation resulting in increase in Heart Rate and Arterial blood pressure. These hemodynamic adverse effects are minimized by multiple non pharmacological methods and pharmacological agents including alpha 2 agonists such as Dexmedetomidine. Dexmedetomidine has a shorter duration of action and effectively attenuates the hemodynamic response of laryngoscopy and endotracheal intubation during the peri operative period. The aim of our study is to compare two doses (0.6mcg/kg and 1mcg/kg) of the drug in effective attenuation of the sympathetic stimulation. Methodology: 80 patients assessed under ASA 1 – 2 between the age group 18-60 years of both genders were included in this study and randomly divided into two groups namely GROUP A – 0.6mcg/kg Dexmedetomidine and GROUP B – 1mcg/kg of the same drug 10mins before induction. Heart rate, Systolic Blood pressure, Diastolic blood pressure, Mean arterial pressure and SpO2 were recorded at various intervals. Results: In both groups, HR, SBP, DBP and MAP reduced significantly. During intubation, 1 and 3 minutes following intubation there was minimal rise in blood pressure in Group A while in Group B the decrease in pressure was marked and continuous. Conclusion: Both doses of Dexmedetomidine (0.6mcg/kg and 1mcg/kg) attenuated the stress response of laryngoscopy and intubation effectively. The reduction in heart rate, Systolic blood pressure, Diastolic blood pressure and Mean arterial pressure was more in 1mcg/kg group. Hence Dexmedetomidine at a dose of 0.6mcg/kg itself is adequate to control the stress response of laryngoscopy and intubation.
Authors and Affiliations
R Arun Shankar, M S Prasanth Kumar, G Dhanabagyam
Keywords
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- DOI 10.26611/1015815
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