Abstract

Silver nanoparticles (Ag NP) have an interesting potential in drug delivery, gene therapy, molecular imaging and medicine in the cure of diseases that require maintenance of circulating drug concentration or targeting of specific cells or organs. The present study focused on the effect of exposure of AgNP and silver oxide on oxidative stress and nitrosative stress biomarkers in human lymphocytes. In lymphocytes samples evaluated oxidative stress biomarkers such as total antioxidant capacity (TAC), catalase activity (CAT) and nitrosative astress biomarker such as assay nitric oxide radical (NO) after 24,48 and 72 hours. The results showed that AgNP 5 Mmol/ml after 48 hours caused a increasing in the TAC compared to control group. AgNP5 Mmol/ml decreased NO level after 24 hours. Also CAT activity decreased in AgNP5 Mmol/ml compared with silver control group after 72 hours. At all alteration oxidative stress biomarkers in AgNPs was similar to AgO2 groups. Therefore, they may induce oxidative and nitrosative stress expect AgNP5 Mmol/ml in human lymphocyte.

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