CONTROLLED DELIVERY OFHIV DRUG BY USING MUCOADHESIVE POLYMER
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2019, Vol 8, Issue 4
Abstract
One of the novel drug deliverysystems are mucoadhesive drug delivery system.It utilizes the property of bioadhesion of polymers which becomes adhesive on hydration. This delivery system can be used totarget a drug to a particular region of the body for extended period of time.Stavudine a nucleoside analogue of thymidine used in the treatment of HIV. Stavudine has short half-lifeof 2.3hours and is taken twicedaily in large number of patients which leads to no patient compliance. Thus, thedevelopment of mucoadhesive microspheres for controlled release would be advantageous. The objective of this study was to prepare, characterize and evaluatemucoadhesive microspheres of stavudine employing chitosan as coat that is used as natural mucoadhesive polymers. Mucoadhesive microspheres were found to be spherical, discrete, free flowing. Fourier transforms infrared spectroscopy (FTIR) revealed no interaction between drug and polymer(s). Scanning electron microscopy (SEM) shows microspheres were spherical.The microspheres appear with rough surface and encapsulation efficiencyfound to be in range of 72.18% to80.65%. All the microspheres showed good mucoadhesive property and swelling index. The drug release was found to be in range of 94.57% to 87.66% over the period of 12 hours.
Authors and Affiliations
Nripendra Singh, Ritu Singh, Surendra Kumar Singh, Sudhir K. Upadhyay
Keywords
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- EP ID EP649427
- DOI 10.7897/2277-4572.084144
- Views 57
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