Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
Journal Title: Journal of Clinical Research in Pediatric Endocrinology - Year 2009, Vol 1, Issue 3
Abstract
The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes children with constitutional delay of growth and puberty, familial short stature, or both, as well as those with subtle cartilage and bone dysplasias. In rare cases, ISS is due to IGF molecular abnormalities. In this review we tackle the major challenges in the definition and treatment of ISS. DOI: 10.4008/jcrpe.v1i3.53
Authors and Affiliations
Stefania Pedicelli, Emanuela Peschiaroli, Enrica Violi, Stefano Cianfarani
Keywords
Related Articles
- EP ID EP113196
- DOI -
- Views 122
- Downloads 0
Insulin Oedema in Newly Diagnosed Type 1 Diabetes Mellitus
Despite the essential role of insulin in the management of patients with insulin deficiency, insulin use can lead to adverse effects such as hypoglycaemia and weight gain. Rarely, crucial fluid retention can occur with i...
Evaluation of Permanent Growth Hormone Deficiency (GHD) in Young Adults with Childhood Onset GHD: A multicenter study
Background: Reconfirming the diagnosis of childhood onset growth hormone deficiency (GHD) in young adults is necessary to demonstrate the need for continuation of GH therapy. Objective: This nationally-based study was p...
Genetics of Growth Hormone Deficiency
From the initiation of the primordium to the expression of mature growth hormone (GH)1 gene, a variety of genes, transcription factors, signalling pathways, and epigenetic control factors take part in the embryological d...
Permanent Central Diabetes Insipidus with Complete Regression of Pituitary Stalk Enlargement After 4 Years of Follow-up
A 14 year-old patient was admitted because of a history of polyuria and polydipsia. A diagnosis of central diabetes insipidus (CDI) accompanied by growth hormone (GH) and gonadotropin deficiency was made. Hypophyseal mag...
The relationship between serum ghrelin levels and hair zinc concentrations in children
Background: Zinc (Zn) plays a central role in the activation of numerous enzyme systems that synthesize and degrade bioactive peptides. Some of these bioactive peptides, also called neuropeptides, are involved in the reg...