Correlation between MRI burden of cerebral small vessel disease and cognitive impairment in elderly hypertensive people
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2025, Vol 51, Issue 1
Abstract
[Objective] To evaluate the correlation between MRI burden of cerebral small vessel disease and cognitive impairment in elderly hypertensive people. [Methods] Data of elderly hypertensive people with CSVD at Xingtai People’s Hospital Affiliated to Hebei Medical University from January 2018 to September 2024 were analyzed. According to the total MRI burden score, patients were divided into mild to moderate (0-2) and severe (3-4) burden groups. The baseline data and cognitive impairment were compared between groups. The correlation between risk factors of MRI burden and cognitive impairment was analyzed. [Results] The severe burden group had higher systolic blood pressure [178 (155,180) mmHg vs. 159.50 (147.75,170) mmHg, higher fasting blood glucose [5.70 (5.37, 5.92) mmHg vs. 5.38 (4.83, 5.70) mmHg, P<0.05] and higher the proportion of cognitive impairment [8 (28.1%) vs. 3 (6.8%), P<0.05] than the mild to moderate group. Multivariate logistic regression analysis revealed that systolic blood pressure (OR=1.033, 95%CI: 1.001-1.067, P<0.05) was the independent risk factor for total MRI burden. Spearman correlation analysis revealed that MRI total burden was negatively correlated with MMSE score (r=-0.315, P=0.011) and MoCA score (r=-0.662, P<0.001). Compared with the mild to moderate burden group, the severe group performed worse in the areas of orientation, attention and computation, language ability on the MMSE, and worse in visual space and executive ability, attention, language, delayed recall, and orientation on the MoCA (P<0.05). [Conclusion] Systolic blood pressure is the independent risk factor of MRI total burden in elderly hypertensive people. The higher the total MRI burden, the more severe the cognitive impairment, the worse performance in orientation, visual space and executive ability, attention and computation, language, and delayed recall.
Authors and Affiliations
Jie LI, Linyi JIA, Fengxiao GAO, Wensheng WANG, Bingxin. PANG
Keywords
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- EP ID EP762100
- DOI 10.3969/j.issn.1002-0152.2025.01.003
- Views 9
- Downloads 0
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