CORRELATION BETWEEN NEONATAL SEPSIS WITH SERUM CRP AND PLATELET INDICES (PLATELETS COUNT, MPV & PDW
Journal Title: INTERNATIONAL JOURNAL OF ADVANCED MEDICINE - Year 2017, Vol 1, Issue 6
Abstract
Background of study: Neonatal sepsis causes signicant mortality and long term morbidity in neonates, especially for preterm infants of very low birth weight. Objective: To ndout correlation between neonatal sepsis with serum CRP and platelet indices (platelets count,MPV,PDW). Method: The study was hospital based prospective study conducted in Department Of Pediatrics associated group of hospitals, Government Medical College ,Kota. Total 256 babies were enrolled who were admitted in NICU and showed signs and symptoms of sepsis and who fullled inclusion and exclusion criteria. Peripheral venous blood was collected from all the newborns for all laboratory investigation. All the data were collected and analyzed using software SPSS version 21. Results: Among the positive perinatal sepsis (26.56%), maternal fever (57.35%) and PROM (30.88%) was the most common causes. 66.41% were sepsis screen positive and 35.55% were blood culture positive. Serum CRP was positive in 58.20% cases, thrombocytopenia(<1.5 lac), MPV(>10.8), and PWD(>19.1) was present in 81.25%, 73.44%, and 69.14% cases respectively. Sepsis was occurred most commonly due to gram negetive organism. Most common organism causing sepsis was kleibsiella (39.56%). Among the CRP positive cases, 36.91% had blood culture positive. Sensitivity, specicity, PPV, and NPV of CRP for proven sepsis was 60.44%, 43.03%, 36.91% and 66.36% respectively. Platelets count was more decrease in LOS (p=0.005). Sensitivity and specicity of platelet counts (<1.5 lac), MPV(>10.8), and PWD(>19.1) were 87.91%, 84.62%, 79.12% and 22.42%, 32.73%, 36.36% respectively. When we combine all three parameter of platelets indices (Count+MPV+PDW), we achieve highest sensitivity (98.33%) and NPV (95.65%). Conclusion: In this study we conclude that the marker of platelets indices has higher diagnostic efficacy than CRP; the platelets indices had higher sensitivity, NPV, and PLR. High PDW, high MPV and low platelets counts are more associated with neonatal sepsis. So this study is useful for evaluating platelets indices as a marker of neonatal sepsis alone or with combination to pre-existing sepsis screen.
Authors and Affiliations
Dr. Ishwar lal Meena, Dr. Rajendra singh Gurjar, Dr. Gopikishan Sharma, Dr. A. L. Bairwa
Keywords
Related Articles
- EP ID EP626888
- DOI -
- Views 72
- Downloads 0
PREVALENCE OF PRIMARY DRUG RESISTANCE TO RIFAMPICIN AND ISONIAZID IN NEWLY DIAGNOSED SPUTUM SMEAR POSITIVE PULMONARY TUBERCULOSIS
Aims and objective: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients. Material and method: A...
POLYPHARMACY, CHARACTERISTICS OF THE MEDICATIONS USAGE IN THE ELDER PATIENTS IN EMERGENCY ROOM
Introduction: Polypharmacy, the concurrent use of ve or more medications, highly risks connected for the medication-medication interaction, medication-disease and therapeutic competition (recommended treatment for a dis...
CLINICAL PROFILE OF HOSPITALIZED CHILDREN WITH FEBRILE SEIZURES
Objective: The objectives of this study were to evaluate the clinical prole, investigations, course in hospital and outcome of children admitted with febrile seizures. Methods: 70 children with febrile seizures were tak...
CARDIAC DYSFUNCTION IN PATIENTS WITH HYPOTHYROIDISM IN ADULTS
BACKGROUND: Hypothyroidism is a graded disorder and its cardiovascular effects need further exploration. METHODS: In this prospective case control study, we evaluated, 50 newly diagnosed hypothyroid patients and 25 age a...
CLINICAL PROFILE OF INTRA-CEREBRAL HAEMORRHAGIC STROKE PATIENTS IN AN ETHNIC POPULATION OF NORTH INDIA
Introduction: Given the high prevalence of Intra Cerebral Haemorrhage (ICH) in the Kashmir Valley, an associated very high morbidity and mortality and the scarcity of studies from our part of the world it becomes relevan...