Correlation between Statin use and Intracranial Haemorrhage
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
Background: Intracerebral haemorrhage (ICH) is a neurologic injury resulting in significant morbidity and mortality. Statins play a significant role in primary and secondary prevention of cardiovascular and cerebrovascular ischemic events. Despite clear benefits of statins in ischemic stroke, studies suggest there may be a link between statin therapy and development of ICH. Aims and Objectives: To find the correlation between statin use and intracranial haemorrhage. Methods and Results: Retrospective study among 50 patients with intracranial haemorrhage. Detailed history including co-morbid conditions (especially HTN and IHD), intensity of statin used, severity of IC bleed, fasting lipid and GCS were obtained and analysed. IC bleed was classified into mild (less than 30cc), moderate (30 to 100cc) and severe (more than 100cc) based on volume of IC bleed on CT brain. Correlation was obtained between statin use and intracranial haemorrhage. Results and Conclusion: The study found out that statin users had larger bleed volume, low GCS, lower total cholesterol and LDL levels. Also observed in the study was higher the intensity of statins more severe is the IC bleed. IC bleed also correlated with higher age, male sex, hypertension and IHD.
Authors and Affiliations
Dr Muralidhar. H
Keywords
Related Articles
- EP ID EP515517
- DOI -
- Views 64
- Downloads 0
Tadalafil therapy in symptomatic improvement of LUTS due to BPH and associated Erectile Dysfunction
Introduction: Benign prostatic hyperplasia, one of the most common urological problem in aging man, is a complex disease and is often associated with bothersome LUTS. Objective: The aim of present study was to assess the...
Beta Cell Dysfunction, Insulin Resistance and Impaired Insulin Sensitivity in Obese Adolescents
Introduction: Changes in food consumption and health habits that have developed over the last three decades, the prevalence of obesity in children and adolescents has increased in both developed and developing countries....
Beta-Catenin Expression in Gallbladder Tissues and Its Role in Carcinogenesis and Tumor Progression in Gallbladder Carcinoma
Background: Gallbladder carcinoma is the most common malignancy in the biliary tract, the fifth commonest cancer of the gastrointestinal tract. Oncogenes (beta-catenin) has been shown to be involved in the development an...
A Study of Risk Factors Causes Bone Injury in Osteoporotic Individuals
Osteoporosis is characterized by low bone mass with micro architectural deterioration of bone tissue leading to enhance bone fragility, thus increasing the susceptibility to fracture. Osteoporotic fractures in India occu...
Clinical Correlation between McISSAC Score and Throat Swab Culture In Predicting Streptococcal Pharyngitis In Patients Presenting With Sore Throat
Introduction: GAS pharyngitis is both antecedent for invasive streptococcal infection and post infectious immunologic complication of Rheumatic fever/RHD, a leading cause of cardiovascular morbidity and mortality in many...