Correlation of HbA1c with Mortality and severity in Acute Coronary Syndrome
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 8
Abstract
Introduction: Coronary Artery Disease (CAD) has emerged as the single most important cause of death worldwide and as well as in India. Diabetes Mellitus (DM) is a major risk factor for CAD and there appears to be a graded rise in cardiovascular risk with increasing degrees of glucose intolerance well below the definition of overt diabetes. The aim of the study was to define the relationship between HbA1c levels with mortality, morbidity and severity in patients with Acute Coronary Syndrome (ACS). Material and Methods: This was an observational prospective study. The sample size was 110 patients with ACS. Detailed history, examination and investigations were done as per preformed proforma. ECG, CPK-MB, echocardiography was done in all patients and coronary angiography (CAG) was done in half of the patients. Results: The mean age was 58.17 ± 9.87. Out of 110 patients, 64 (57.2%) were non-diabetic, 27 (24.5%) were diabetic and 20 (18.2%) had impaired glucose tolerance 46 patients (41.8% of patients) had hypertension. The most common complications were left ventricular dysfunction (LVD) and Heart Failure (HF) and this were significantly more present in diabetics compared to nondiabetics (p value 0.009). The mean HbA1c level was higher in patients with complications (6.61 ± 2.13) than in patients with complications as compared (5.90 ± 1.27) in patients without complications. Conclusion: ACS can be presenting manifestation of DM thus each patient of ACS should be screened for diabetes and glucose intolerance. Patients with DM when compared to nondiabetics have increased morbidity and severity after an ACS.
Authors and Affiliations
T. N. Dubey, Kaustubh Mundada, A Arya
Keywords
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