Correlation of Histological Grade with Harmone Receptors and Her 2 Neu In Carcinoma Breast - A Tertiary Centre Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 5
Abstract
Introduction: Hormone receptors and Her 2 Neu status are now widely accepted as a prognostic markers and to decide therapeutic modality in breast carcinoma. The aim of this study was to analyze the receptor status in breast carcinoma with histopathological characteristics of the tumor. Material and Methods: In the present study, immunohistochemical assay of 60 tumor block of patients of breast carcinoma was performed to know the hormone receptor status as well as histological examination. Results:. 60 breast cancer specimen were available for immunohistochemical testing for ER/PR. The result of the study showed that only 3.33% cases were ER+/PR+, 7.66% cases ER+/PR-, 9.33% ER-/PR+ and 80% cases were ER-/ PR-. Expression of ER and PR was found to be significantly associated with tumor grade. Conclusion: The Estrogen receptor and Progestrone Receptor negative cases were found in high grade disease on histological evaluation. Their status should be ascertained in all cases of breast carcinomas. Triple negative breast carcinomas have poorer prognosis as they tend to be of high grade.
Authors and Affiliations
Shiv Pankaj Khanna, Rigvardhan .
Keywords
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