Correlation of Inverse Expression of E-Cadherin andAutocrine Motility Factor Receptor with Increased Dedifferentiation ofPancreatic Adenocarcinoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 2
Abstract
Pancreatic adenocarcinoma though relatively rare , have dismal prognosis.With intention to find if simultaneous occurrence of destruction of intercellular adhesion is associated with propagation of carcinomatous cells, we studied different grades and stages of pancreatic adenocarcinoma and noted expression of E-cadherin( ECAD) ,strongest intercellular adhesion molecule of epithelial cells and Autocrine Motility Factor Receptor (AMFR) ,the known propagator of cancer cell with aid of immunohistochemistry in a retrospective study. Paraffin blokes of 19 patients who were treated with Pancreaticoduodenectomy (Whipple procedure),Distalpancreatectomy, Total pancreatectomy was processed through standardized protocols and scrutinized with predetermined parameters. Normally in non-malignant pancreatic epithelium, strong ECAD and Weak AMFR is visible, with tumour dedifferentiation, reverse manifested.In comparison to Grade3 tumours, Grade 1 Pancreatic Duct Adenocarcinomas in our study revealed strong ECAD (52.6% vs. 5.2%) and less AMFR ( 36.8% vs. 100 %)expression.Incrementof tumour stage was found associated with strong AMFR and Weak ECAD expression.Study of coexpression of these two molecules could partly explain different histologic grades of pancreatic adenocarcinoma ,their properties as well as indicated towards their synergistic critical play in process of progression of cancer cell.
Authors and Affiliations
Dr. Debashis Roy Burman
Keywords
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- EP ID EP580472
- DOI 10.9790/0853-1702055561
- Views 36
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