Correlation of Long Term Chronic Renal Disease (CKD) With Intact PTH (iPTH) and Biochemical Parameters

Journal Title: International Journal of Pharma Research and Health Sciences - Year 2016, Vol 4, Issue 2

Abstract

Alteration in macro-mineral system and abnormal status of parathyroid hormone (PTH) level are common in patients with chronic kidney disease (CKD). It is also documented that hyperparathyroidism is a condition developed secondary to CKD, subsequently causing abnormal mineral metabolism which leads to end stage renal disease (ESRD). The objective of present study is to evaluate intact PTH (iPTH), macro-mineral status and Vit D3 in short and long duration CKD patients from both genders. Current study covers the period of Dec 2013 to Dec 2015 and conducted at Department of Biochemistry Laboratory services and Chemical Pathology, Liaquat National Hospital and Medical college-Karachi and Govt Lyari General Hospital Karachi. Selections of patients were made according to the specialty of nephrology, diabetic, non-diabetic, and those on hemo-dialysis or peritoneal dialysis with males = 50 and females = 30 patients. All biochemical and hormonal parameters were determined by standard methods. Results showed patients of both genders exhibiting similar pattern of PTH concentration and biochemical parameters. In female patients’ group, maximum duration of renal disease and process of dialysis was 3.5 ± 2.10 years where as in male patients; it was 5.45 ± 3.25 years. None of the patients assessed from both gender groups exhibited protein to creatinine ratio (P:C ratio) greater than 1, however their creatinine clearance was noted to be way below normal ranges. Intact PTH, Ca, P, uric acid, albumin and Vit D3 were all observed to be altered significantly (P < 0.01 to P < 0.001). Our data exhibited significant correlation of CKD with biochemical parameters, especially iPTH, cCT, calcium, phosphorus and Vit D3. Moreover, duration of CKD also showed influence on the levels of iPTH, such that longer the duration, higher shall be the iPTH in patients from both genders.

Authors and Affiliations

Keywords

Related Articles

Exotic Pepino: A Shrub for Prophylactic Consequence & Nutritional Regime

The pepino (Solanum muricatum) is an herbaceous Andean domesticate grown shrub for its juicy and aromatic fruits. Although it was a very important crop in the Andean region in pre-Columbian times, its 20th century promin...

Phytochemical Studies of Phyllanthus emblica, Ananas comosus, Momordica charantia Extracts

The present study was carried out to screen phyto constituents and evaluate the antioxidant activity of Phyllanthus emblica, Ananas comosus, Momordica charantia extracts and its potential as preservative. The antioxidant...

An Efficient Approach for Thio-Ether Bond Formation in Carbetocin

An efficient approach for the formation of unnatural thio-ether side chain of carbetocin by performing the reaction using DMF and liquid Ammonia to produce Crude Carbetocin. Crude carbetocin SH was synthesized by solid p...

Some Medicinal and Aromatic Plants from the Districts of West Bengal Used in the Treatment of Kidney Stones Along With Their Status

India is the largest producer of Medicinal and Aromatic plants and as such is known as the "Botanical garden of the World". These Medicinal and Aromatic plants have tremendous potential in having natural therapeutic valu...

Method Development and Validation for the Simultaneous Estimation of Pseudoephedrine and Loratidine in Bulk and Pharmaceutical Dosage Form Using RP-HPLC

A simple specific, accurate and precise RP-HPLC method has been developed for the simultaneous estimation of Pseudoephedrine and Loratidine in pharmaceutical dosage form. The Isosbestic point for Pseudoephedrine and Lora...

Download PDF file
  • EP ID EP325632
  • DOI -
  • Views 85
  • Downloads 0

How To Cite

(2016). Correlation of Long Term Chronic Renal Disease (CKD) With Intact PTH (iPTH) and Biochemical Parameters. International Journal of Pharma Research and Health Sciences, 4(2), -. https://europub.co.uk/articles/-A-325632