Abstract

Alteration in macro-mineral system and abnormal status of parathyroid hormone (PTH) level are common in patients with chronic kidney disease (CKD). It is also documented that hyperparathyroidism is a condition developed secondary to CKD, subsequently causing abnormal mineral metabolism which leads to end stage renal disease (ESRD). The objective of present study is to evaluate intact PTH (iPTH), macro-mineral status and Vit D3 in short and long duration CKD patients from both genders. Current study covers the period of Dec 2013 to Dec 2015 and conducted at Department of Biochemistry Laboratory services and Chemical Pathology, Liaquat National Hospital and Medical college-Karachi and Govt Lyari General Hospital Karachi. Selections of patients were made according to the specialty of nephrology, diabetic, non-diabetic, and those on hemo-dialysis or peritoneal dialysis with males = 50 and females = 30 patients. All biochemical and hormonal parameters were determined by standard methods. Results showed patients of both genders exhibiting similar pattern of PTH concentration and biochemical parameters. In female patients’ group, maximum duration of renal disease and process of dialysis was 3.5 ± 2.10 years where as in male patients; it was 5.45 ± 3.25 years. None of the patients assessed from both gender groups exhibited protein to creatinine ratio (P:C ratio) greater than 1, however their creatinine clearance was noted to be way below normal ranges. Intact PTH, Ca, P, uric acid, albumin and Vit D3 were all observed to be altered significantly (P < 0.01 to P < 0.001). Our data exhibited significant correlation of CKD with biochemical parameters, especially iPTH, cCT, calcium, phosphorus and Vit D3. Moreover, duration of CKD also showed influence on the levels of iPTH, such that longer the duration, higher shall be the iPTH in patients from both genders.

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