Abstract

Wounds are inescapable events of life, which arise due to physical or chemical injury or microbial infections. Wound healing is a complex and protracted process of tissue repair and remodeling in response to injury. As per the conventional pharmaceuticals, the overuse of synthetic drugs for wound healing such as topical antibiotics create a development of antibiotic resistance because of inadequate penetration for deep skin infections. A recent study has shown that biofilm formation by certain bacteria has become an important virulence factor associated with the generation of secondary resistance because antimicrobials are not able to penetrate into the biofilm to completely eliminate the organisms. So, there is need of some alternatives to inhibit growth of bacteria on wounds. Since ancient time, plants are already proved to be a natural remedy for various ailments. Preparations from traditional medicinal plants are often used for wound healing purposes covering a broad area of different skin-related diseases. Herbal preparations can be more effective than conventional medicines and their non-toxic nature means that they can be administered over long periods. Herbal medicines in wound management involve disinfection, debridement, and provision of a suitable environment for aiding the natural course of healing. Today drug delivery experience several challenges, where hydrogel could be one potential answer to those. Hydrogel are one of the most popular types of wound dressings. Because they have been found to promote fibroblast proliferation by reducing the fluid loss from the wound surface and protect the wound from external noxae necessary for rapid wound healing. The major advantage of using hydrogels is that they are used as simple encapsulation of cells or drugs in homogenous materials. Hence this review explains the necessity of novel drug delivery system for herbal formulation to provide magnificent effect on wound healing capacity.

Authors and Affiliations