Correlations of Serum Cu+2, Zn+2, Mg+2 and HbA1c in Type 2 and Type 2 Diabetes Mellitus
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2004, Vol 8, Issue 2
Abstract
Type 2 Diabetes Mellitus (DM) is one of the most frequently seen. Type 2 DM shows identical patophysiological features with Type 1 DM but differs in etiology. There are lots of studies in the area of both types of DM which are influencing body by metabolic and oxidative stress. In this study serum Cu, Zn and Mg levels are determined in three patient groups (Type 1 DM, obese Type 2 DM, non-obese Type 2 DM) and discussed the relationships with serum cholesterol,trigliserid, glucose and blood HbA1C levels. Study groups evaluated as 21 healty person, 26 non-obese Type 2 DM patients (Body mass index<25), 28 obese Type 2 DM patients (BMI>30), 18 Type 1 DM patients While we didn’t find any correlation between parameters of obese Type 2 DM patients, there was slightly negative correlation (r=-0,521, p<0,05) between Cu and Mg, also the same but positive correlation was found between serum Cu and glucose (r=502, p<0,05) levels in non-obese Type 2 DM patients. In Type 1 DM group; there was strong negative correlation (r= -0,604, p<0,05) between serum Cu and Mg levels with a positive strong correlation (r= 0,774, p<0,001) between serum Cu and blood HbA1C levels. In this group there was also strong negative correlation (r=-0,895, p<0,001) with serum Mg ve blood HbA1C . Serum copper levels was increased in all three patients groups, respectively non-obese Type 2 DM, obese Type 2 DM and Type 1 DM group (p<0.05, p=0,001, p<0,001). The meaningful decrease in serum Mg levels (p<0.05) was only found in Type 2 DM group. There were no significant alterations in levels of serum Zn (p>0,05). The results showed that the determination of serum Zn level is not enough to assess the oxidative stress in DM. Because of the probable lacking of serum Zn/Cu antagonism, serum Cu and Mg levels should be determined. In DM, blood HbA1C levels change the profile of trace elements so can be used to assess tha degree of oxidative and metabolic stress.
Authors and Affiliations
Osman Evliyaoğlu, Levent Kebapçılar, Nuriye Uzuncan, Nazife Kılıçaslan, Baysal Karaca, Ruhan Kocaçelebi, Naciye Yensel
Keywords
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