Could membrane lipids influence the receptor tyrosine kinase activity? Epidermal growth factor receptor and its interactions with gangliosides
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 11
Abstract
Cell membrane is a complex structure. Recently great attention is devoted to specialized membrane fragments responsible for compartmentalization of cellular processes called lipid rafts. Lipid rafts are made of a combination of cholesterol, sphingolipids, including glycosphingolipids, and proteins among them a number of receptors. The glycosphingolipids, especially gangliosides, have been proven to play crucial roles in the regulation of biological functions of raft localized proteins under both physiological and pathological conditions. Gangliosides modulate activity of protein receptors activated by fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), nerve growth factor (NGF), insulin, and epidermal growth factor (EGF). One of the most interesting mechanism of regulation of receptor activity by gangliosides has been shown for epidermal growth factor receptor (EGFR). EGFR activity is dependent on ganglioside composition in its vicinity. Thus GM1 or GD1a gangliosides enhance EGFR activity while GM3 is a well-known EGFR inhibitor. Probably the different ways by which gangliosides influence the EGFR activity is associated with specific structures of both the ganglioside molecule and EGFR. Numerous studies proved direct interaction between these two types of molecules. This interaction could possibly prove to be crucial in the treatment of invasive cancers.
Authors and Affiliations
Natalia Fedoryszak-Kuśka
Keywords
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