Current trend in medical expulsive therapy (MET) for the treatment of ureteral stones
Journal Title: JOURNAL OF MEDICAL COLLEGE CHANDIGARH - Year 2015, Vol 5, Issue 1
Abstract
Medical expulsive therapy (MET) has been described as an effective conservative treatment option for small ureteral stones. The agents that have been investigated include NASAIDs, corticosteroids, calcium channel blockers, α-1 adrenergic blockers and most recently PDE inhibitors. NASAIDs have no role in medical expulsion of ureteral stone. Despite, the fact that corticosteroid and nifedipine have received great attention as potential useful adjunctive but they are not recommended as monotherapy. To date, only α-1 adrenergic blockers are recommended as monotherapy for MET in distal ureteral stones. The new drug called silodosin has shown much better result in some recent study. Although, PDE inhibitors are novel alternative treatment option but require further investigation. This review provides an overview of recent MET best practice guidelines and various agents in current use.
Authors and Affiliations
Mahesh Chandra
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