Cyclooxygenase-2 and Vascular Endothelial Growth Factor Expression and Their Correlation with Angiogenesis in Gastric Carcinomas
Journal Title: Meandros Medical and Dental Journal - Year 2016, Vol 17, Issue 1
Abstract
Objective: The aim of this study was to investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in gastric carcinomas and lymph node metastasis and their relationship with angiogenesis and prognostic histopathological parameters. Materials and Methods: COX-2 and VEGF expression and microvessel density (MVD) grade identified by antibodies against CD34 were investigated immunohistochemically in 33 patients with gastric carcinoma. Results: The expression of COX-2 was 96.9% in normal mucosa and 87.8% in gastric carcinoma. Although COX-2 expression in mucosa was higher than in carcinoma, the difference was not statistically significant. The COX-2 positivity rates in lymph nodes were significantly higher in patients with vascular invasion (p<0.01). The expression of VEGF was 100% in normal mucosa and 93.9% in gastric carcinoma. VEGF levels in mucosa were significantly higher than in carcinoma (p=0.05). MVD grade in mucosa was significantly higher than in gastric carcinoma (p<0.01). MVD values were significantly higher in poorly differentiated carcinomas than in well and moderately differentiated carcinomas (p<0.05). There was no association between COX-2 and VEGF expression and MVD grade in tumor tissues and metastatic lymph nodes. There was no correlation of clinicopathological parameters with COX-2 and VEGF expression and MVD grade. Conclusion: Our results suggest that the MVD in gastric carcinoma may correlate with tumor grade, but the precise roles of COX-2 and VEGF in gastric cancers are not yet fully understood. Further studies with large series are needed to clarify the importance of COX-2, VEGF and MVD in cancer progression.
Authors and Affiliations
Özlem Ekici, Çiğdem Tokyol, Fatma Hüsniye Dilek, Fatma Aktepe, Önder Şahin, Dursun Ali Şahin
Keywords
Related Articles
- EP ID EP235919
- DOI 10.4274/meandros.1038
- Views 117
- Downloads 0
Accuracy of Proximal Caries Depth Measurements: Comparison of Two Computed Cone Beam Tomography and Storage Phosphor Plate Systems
Objective: The aim of this study was to compare the accuracy of NewTom 9000 [cone beam computerized tomography (CBCT)], Accu-I-Tomo [limited CBTC (LCBCT)] and Digora Optime [storage phosphor plate (SPP)] imaging systems...
Antibacterial Efficiency of Different Irrigation Solutions, Lasers and Photodynamic Therapy with Indocyanine Green in Root Canals Infected By Enterococcus Faecalis
Objective: The aim of this study was to evaluate bacterial reduction after using different irrigants, lasers and photodynamic therapy (PDT) in root canals infected by Enterococcus faecalis. Materials and Methods: Seventy...
Evaluation of Complications Following Impacted Mandibular Third Molar Extraction in Patients with Different Hand Preference
Objective: Individual preference of using right or left hand for doing various hand workings, is the most easily observable form of the cerebral lateralization. It was stated that, among the right or left hand dominant i...
Fascioperichondrial Flap with a Proximal Base Combined with Prominent Ear Surgery
Objective: In this article, we present a personalized surgical technique to relocate a fascioperichondrial flap with a proximal base as an additional measure to improve results and hide sharp edges which frequently occur...
Alcoholic Neuropathy with Superimposed Focal Entrapment Neuropathies
We reported here a case of alcoholic polyneuropathy with superimposed focal entrapment neuropathies. A 55-year-old male patient was admitted to the electrophysiology unit with the diagnosis of left ulnar neuropathy. He h...