Cystatin C as potential marker of Acute Kidney Injury in patients after Abdominal Aortic Aneurysms Surgery – preliminary study
Journal Title: Annales Academiae Medicae Silesiensis - Year 2014, Vol 68, Issue 1
Abstract
INTRODUCTION The management of asymptomatic abdominal aortic aneurysms (AAA) includes elective surgery. Among perioperative complications, postoperative acute kidney injury (AKI) appears to be one of the most severe. A rise in serum creatinine (sCr) may not be noticed in the early stage of AKI. According to some reports, a higher level of AKI novel biomarker-cystatin C (CysC) can be detected in serum 24–48 hours earlier than an increase in the sCr level. The purpose of this study was to compare CysC and sCr as indicators of the early phase of AKI in patients after AAA surgery. METHOD The study protocol included patients classified for elective AAA surgery. The ultimate number of patients who fulfilled the inclusion criteria and did not meet the criteria for exclusion from the study was 14. CysC and sCr were measured one day before surgery (day-1) and 12, 24, 48 and 72 hours after surgery. The operative time and aortic clamping time were also recorded. RESULTS There was a tendency for both sCr and CysC to rise, though not significantly. No statistically significant connection was shown between the aortic clamping time release and sCr and CysC. The correlation between sCr and serum CysC re-vealed a statistical significance (p < 0.05). No correlation was shown between sCr and CRP nor CysC and CRP. CONCLUSIONS The CysC serum level is not superior to the sCr level in the diagnosis of AKI after AAA surgery.
Authors and Affiliations
Anna Bekier-Żelawska, Michał Kokot, Grzegorz Biolik, Damian Ziaja, Krzysztof Ziaja, Mirosława Janowska, Małgorzata Starzewska, Jan Duława
Keywords
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