CYTOHISTOPATHOLOGICAL CORRELATION OF NEOPLASTIC AND NON-NEOPLASTIC LESIONS OF LYMPH NODE- A DIAGNOSTIC TEST VALIDATION STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 45
Abstract
BACKGROUND Fine needle aspiration cytology is a simple and cost effective technique that is routinely used in patients presenting with persistent lymphadenopathy. FNAC is a first line investigation modality for evaluation of lymphadenopathy. Aetiology of lymphadenopathy in head and neck region varies from reactive hyperplasia to tuberculous granulomatous lesion to malignancy. The aim of the present study is to compare the accuracy of FNAC in the diagnosis of neoplastic lymph node disease with that of non-neoplastic diseases. MATERIALS AND METHODS This descriptive retrospective study was undertaken at Pathology Department, Government Medical College, Thiruvananthapuram over a period of two years. Out of 1020 lymph node aspirations received in our cytology department, a total of 122 cases were identified and included in this study where both cytology and biopsy material were available for review. All the diagnosis obtained by fine needle aspiration cytology was correlated with histopathology. RESULTS Out of 122 lesions in this study, 77 cases were non-neoplastic and 45 cases were neoplastic. The best diagnostic accuracy on cytohistopathological correlation was in cases of metastatic carcinoma (89%) followed by Non-Hodgkin’s lymphoma (88.8%), reactive hyperplasia (79.2%) and tuberculosis lymphadenitis (71.4%) respectively. The overall accuracy of non-neoplastic lymph node lesions by FNA was found to be 91.8%, sensitivity 99.2% and specificity 84.3%. In neoplastic lymph node lesions of FNA, the overall accuracy was found to be 98.4%, sensitivity 100% and specificity 97.5% CONCLUSION FNAC is an important diagnostic tool for diagnosing benign as well as malignant lesions. Findings in this study are comparable and consistent with studies conducted elsewhere. In the present study, it is observed that the accuracy of FNAC is marginally more in diagnosing neoplastic nodal diseases than non-neoplastic nodal diseases.
Authors and Affiliations
Sheela K. M, Priya M. G
Keywords
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- EP ID EP216825
- DOI 10.14260/Jemds/2017/759
- Views 77
- Downloads 0
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