CYTOLOGICAL GRADING OF DUCTAL CARCINOMA OF BREAST IN FINE NEEDLE ASPIRATES AND ITS CORRELATION WITH HISTOLOGICAL GRADING
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 84
Abstract
BACKGROUND Grading of fine needle aspirates of breast carcinoma is useful for selection of appropriate therapy, especially for planning neoadjuvant chemotherapy. The aim of this study is to evaluate the cytological grading by Robinson method in FNAC samples and to correlate it with the well-known prognostic factor. Histological grading system proposed by Nottingham Modification of Bloom-Richardson. The cytologic grading system was also correlated with the axillary lymph node status. MATERIALS AND METHODS This descriptive study was done on fifty female patients with breast lump in Department of Pathology in Coimbatore Medical College. Cytological samples were stained using H and E stain and Papanicolaou stain. Cytologic grading was done by Robinson method and compared with Nottingham modification of Scarff-Bloom-Richardson method histologic grading system. RESULTS Most of the tumours were Grade 2 tumours (46%). The concordance between cytological grade and histological grade was 86%, nearly 43 out of 50 cases. The remaining 7 cases (14%) showed discrepancy. Among these cases, five were upgraded and two were downgraded. The association between cytological grade and histological grade were statistically significant (p < 0.05). The Lymph node positivity was noted among 37.5%, 52.17% and 72.7% of Grade 1, 2 and 3 tumours respectively. High grade tumours show increased nodal positivity. The association between cytological grade and lymph node status was not statistically significant (p > 0.05). Most of the tumours were T2 (2 - 5 cm). The association between tumour size and cytologic grade was not statistically significant (p > 0.05). Most of the tumours were located in outer quadrant 50%, higher grade tumours in central quadrant. CONCLUSION This concludes that cytological grading should be included in all FNAC reports of ductal carcinoma of breast, so that appropriate decision can be made regarding the neoadjuvant chemotherapy can be taken and overtreatment of low-grade carcinomas can be avoided.
Authors and Affiliations
Hidhaya Fathima K, Nilavu J
Keywords
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- EP ID EP276816
- DOI 10.14260/jemds/2017/1270
- Views 73
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