Cytological spectrum in patients of gastro-esophageal reflux disease: A prospective study in a tertiary care institute
Journal Title: International Journal of Biomedical Research - Year 2018, Vol 8, Issue 6
Abstract
Gastroesophageal reflux disease (GERD) is defined as reflux of gastric contents into mouth resulting in restrosternal burning sensation. Aims: This prospective study was undertaken with the aim to assess the cytological spectrum in esophageal brushings taken from patients with GERD and there correlation with esophageal biopsy. Method: Esophageal brushings and biopsies were taken from 150 patients of GERD and 50 controls. GERD cases were defined by the presence of classical symptoms of heart burn and/or acid regurgitation. Endoscopically, GERD cases were subdivided into erosive reflux disease (ERD) and non-erosive reflux disease (NERD). Three cytological parameters studied in esophageal brushings were reactive changes, presence or absence of inflammation and presence or absence of parabasal cells. Results: The most common finding was reactive changes with inflammation (56 cases, 37.33%) followed by inflammatory smears in 12 (8%) patients. Parabasal cells were not seen in any of the subjects with GERD. Presence of reactive changes with inflammation revealed a statistically significant correlation between GERD patients and controls (p<0.05). However, the presence of inflammatory cells did not reveal a statistical significance. (p=0.136). The sensitivity of cytology in our study was 68% and specificity was 95.12%. Conclusion: Cytology cannot be truly relied upon and can only be used as an adjunct to histpathology with both being complementary to each other.
Authors and Affiliations
Shivani Sood, Rajni Kaushik, Anchana Gulati, Brij Sharma, Pranav Sood, Pooja Chauhan, Ganga Rawat
Keywords
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- EP ID EP452414
- DOI 10.7439/ijbr.v8i6.4185
- Views 84
- Downloads 0
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