Cytomegalovirus (CMV) – a new prospect for prevention
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 7, Issue 2
Abstract
Human cytomegalovirus (HCMV), a member of the Betaherpesvirinae subfamily of the Herpesviridae family, is a widespread pathogen. CMV is a virus usually completely harmless to healthy people; nevertheless, it is still a major cause of morbidity and mortality in immunocompromised individuals, such as organ transplant recipients (also haematopoietic stem cel transplantation) and AIDS patients. Furthermore, is a common cause of congenital infections. So far, it is not possible to take effective prevention activities, although there are high expectations in finding an effective vaccine. Understanding the detailed construction of the virus helped to create exactly harmless virus strains used for research. Progress in genetics and biotechnology allowed the carrying out of changes in the virus genome. Today, we know the different parts of the DNA code, are able to modify them, delete, and add inserts. All these actions bring us closer to achieving the objective of an effective and safe vaccine. The presented study shows the results of many different studies and attempts to find an effective vaccine against HCMV. The development direction of research is broad and includes various activities with the use of subunit vaccines, DNA vaccines, peptides and vaccines using the vectors. Some preparations are just at the beginning of a long journey for the registration of an cceptable vaccine, while others have entered into the last phase of clinical trials.
Authors and Affiliations
Małgorzata Polz-Dacewicz, Sylwia Fołtyn, Paweł Macieląg, Dorota Polz
Keywords
Related Articles
- EP ID EP58795
- DOI -
- Views 167
- Downloads 0
Wpływ cyklu nosowego na odpowiedź obrzękową podczas donosowej próby prowokacyjnej z alergenem
Podczas obustronnej donosowej próby prowokacyjnej dochodzi najczęściej do asymetrycznego obrzęku jam nosowych. Przypuszcza się, że zjawisko to może być związane z fazą cyklu nosowego, w której wykonano próbę. Celem prac...
Demographic and health situation of children in conditions of economic destabilization in the Ukraine
Introduction and objective. In new conditions of socio-economic development in the Ukraine, the health of the population of children is considered as the most reliable indicator of socio-economic development of the count...
Anticholinesterase activity of selected phenolic acids and flavonoids – interaction testing in model solutions
[b][/b][b]Introduction[/b]. Alzheimer’s disease is a progressively developing neurodegenerative disorder of the central nervous system. The only present treatment of this disease is the use of acetyl- and butyrylcholines...
Exposure to airborne microorganisms and endotoxin in a potato processing plant.
Microbiological air sampling was performed in a big potato processing plant located in eastern Poland. Air samples for determination of concentrations of microorganisms, dust and endotoxin were collected at 6 sites in th...
Next generation sequencing for preimplantation genetic testing of blastocysts aneuploidies in women of different ages
Most of the current preimplantation genetic screening of aneuploidies tests are based on the low quality and low density comparative genomic hybridization arrays. The results are based on fewer than 2,700 probes. Our mai...