The effects of caffeine administered at different temperatures on foetal development

Journal Title: Annals of Agricultural and Environmental Medicine - Year 2016, Vol 23, Issue 1

Abstract

An easy access to products containing caffeine makes it widely consumed to excess by the general population, including pregnant women. Beverages containing caffeine are consumed at different temperatures (iced, hot, room temperature). Caffeine easily passes through biological membranes, including the blood-brain barrier, the placental barrier, and can also enter the amniotic fluid, breast milk and semen. The aim of this study was to evaluate the relationship between caffeine’s developmental toxicity, and the solution’s temperature (both low and high) administered to pregnant female rats. Fertilized females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30mg/day) in 10 (E[sub]1[/sub]), 25 (E[sub]2[/sub]) and 45[sup]o[/sup]C (E[sub]3[/sub]). The females in the control group were given water at the same temperature (C[sub]1[/sub], C[sub]2[/sub] and C[sub]3[/sub]). On the day 21 of pregnancy, the pregnant females were killed by decapitation, using a specially prepared laboratory guillotine, after which the mothers’ internal organs were weighed. Additionally, the offspring were examined using standard teratological methods. The study found that caffeine administered to pregnant females at a dose of 30mg/day and at the temperatures of 10°C, 25°C or 45°C did not produce any teratogenic effects. The only sign of its adverse effect was the appearance of developmental abnormalities in the form of haematomas and saturated bleeding in the internal organs. These changes most frequently occurred in foetuses of females which received caffeine at 10°C or 45°C.

Authors and Affiliations

Marek Tomaszewski, Franciszek Burdan, Grazyna Olchowik, Monika Tomaszewska

Keywords

Related Articles

Microflora and mycotoxin contamination in poultry feed mixtures from western Poland

Objective: Contamination of feeds with pathogenic microflora and mycotoxins constitutes a serious threat both for animals and humans. The aim of the study was to determine the degree of risk of the occurrence of microsco...

Contact allergy to nickel: patch test score correlates with IL-5, but not with IFN-gamma nickel-specific secretion by peripheral blood lymphocytes.

Traditionally, allergic contact dermatitis (ACD) has been associated with the activity of Th1 lymphocytes that secrete interferon gamma. Recent evidence indicates that other cells, e.g. interleukin 5 (IL-5)-secreting Th2...

Brucellosis in humans – etiology, diagnostics, clinical forms

Brucellosis in humans is a zoonosis of greatly varied clinical image. It occurs on all inhabited continents. The course of the disease may be acute, sub-acute or chronic. The etiologic factors of brucellosis are small,...

Ultrastructural haemomicrocircular channel links of rat testicle in streptozotocin-induced diabetes

The first changes in rat testicle haemomicrocircular channel links ultrastructural arrangement are noticed already in a 2-week run of streptozotocin-induced diabetes mellitus, and accumulate throughout next periods of th...

Pollen spectrum and risk of pollen allergy in central Spain.

The present work analyses the airborne pollen dynamic of the atmosphere of Toledo (central Spain), a World Heritage Site and an important tourist city receiving over 2 millions of visitors every year. The airborne pollen...

Download PDF file
  • EP ID EP79332
  • DOI 10.5604/12321966.1196871
  • Views 132
  • Downloads 0

How To Cite

Marek Tomaszewski, Franciszek Burdan, Grazyna Olchowik, Monika Tomaszewska (2016). The effects of caffeine administered at different temperatures on foetal development. Annals of Agricultural and Environmental Medicine, 23(1), 148-152. https://europub.co.uk/articles/-A-79332