D-Penicillamine Alleviates Oxidative Stress in Neonates by Its Influence on Copper Dyshomeostasis Due to Immaturity
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 2
Abstract
Objective – the aim of this article was to demonstrate the protection of biomembranes against lipid peroxidation, and highlight the role of D-Penicillamine (D-PA). Study Design – The authors conducted a review searching the relevant literature of bilirubin and copper metabolisms, and of antioxidant effects of D-PA in the neonatal period. Results – Unconjugated bilirubin has a special affinity for the globus pallidus, the hippocampus, and the subthalamic nucleus (basal ganglia). Furthermore, immaturity of the blood-brain barrier also contributes to the development of kernicterus. Homeostasis of metal ions usually involves a huge set of proteins which regulate the proper metal biology. Metal ions, especially copper and iron play very important roles in the pathogenesis of neurodegenerative diseases, including bilirubin-induced neurologic dysfunction (BIND), having impact on both protein structure (misfolding) and oxidative stress. D-PA by its ability to modulate both oxidative stress and nitric oxide (NO) pathway may have significant neuroprotective effects in cases jeopardized by BIND or retinopathy of prematurity (ROP). Interpretation – The authors conclude that treatment with D-PA might result in a wide range of health benefits, improved quality of life and reduced healthcare costs and may help reduce complications in the neonatal period.
Authors and Affiliations
Lajos Lakatos MD, György Balla MD
Keywords
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