DENDRIMERS: A NOVEL TOOL FOR DRUG DELIVERY AND TARGETING
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 3
Abstract
Dendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. Due to their unique architecture these have improved physical and chemical properties like high solubility, miscibility and reactivity. Dendrimers consist of well defined size, shape, molecular weight and monodispersity. These properties formulate the dendrimers a suitable carrier in drug delivery application. These are built from number of molecular entities of colloidal particles that exists in equilibrium with the molecules or ions in nature and due to these increases the solubility of poorly soluble drugs. Dendrimers have the ability to encapsulate and bind the guest molecule can be used for solubility enhancement, sustained release and various drug delivery applications. The terminal groups are modified to attach biologically active substances for targeting purpose. Dendrimers are suitable for a wide range of targeted drug delivery, controlled drug delivery, gene delivery and industrial applications. This review gives concise information about the dendrimers, its synthesis, characterization and application in drug delivery.
Authors and Affiliations
Udokwu Japhet Chigbo, Adim Ekene Ugochukwu, Dingwoke Francis John
Keywords
Related Articles
- EP ID EP36396
- DOI https://doi.org/10.22270/ujpr.v2i3.RW5
- Views 286
- Downloads 0
COMPARATIVE ANALYSIS OF THE PHYTOCHEMICAL COMPOSITIONS OF LEAF, STEM-BARK AND ROOT OF AZADIRACHTA INDICA (NEEM)
Plant chemicals abound in different parts of plants, in different compositions. Thus, the comparative screening of the leaf, stem-bark and root of Azadirachta Indica becomes imperative. The presence of nine phytochemical...
DEVELOPMENT AND IN-VITRO EVALUATION OF MATRIX-TYPE TRANSDERMAL PATCHES OF LOSARTAN POTASSIUM
Since last decade drugs through skin has received great attention of many researchers. The aim of present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Losartan potassium...
PREVALENCE OF DYSLIPIDEMIA AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SULAIMANI GOVERNORATE
Rheumatoid arthritis is a systemic inflammatory disease characterized by chronic and erosive polyarthritis it is the most common inflammatory arthritis, affecting from 0.5-1% of the general population. Dyslipidemia is...
DEVELOPMENT AND EVALUATION OF IN SITU GELLING GASTRORETENTIVE FORMULATIONS OF MELOXICAM
The aim of this study was to develop a novel gastro retentive oral floating in situ gelling system for controlled release of Meloxicam. Meloxicam is a NSAID that inhibits cyclooxygenase (COX) synthesis and has analgesic...
EVALUATION OF ANTIDIABETIC DRUG ALOGLIPTIN FOR THE TREATMENT OF INFLAMMATION IN RATS
The present study was planned to evaluate the Alogliptin (Anti diabetic drug) for the treatment of inflammation in experimental models in rats. 5 groups of wister rats of either sex weighing 180- 220 g, selected for the...