Dengue Fever Patients May Develop Proteinuria and Hematuria – A Report of 18 Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Present study relates to the results of urine analysis of 18 patients with Dengue fever. Dengue antigen (Ag) detection was done in sera of patients with febrile illness by ELISAusing monoclonal murine anti-NS1 antibody. All the patients (n = 18) were serum Dengue antigen NS1 positive. Dengue IgM and IgG antibody tests were also done in 11 of 18 NS1 Ag+ sera using micro ELISA kits; one of 11 patients also had Dengue IgM antibody in his serum. Age of the patients ranged from 11 to 78 (median 43) years. Male female ratio was 2:1. Eight of 18 patients had significant proteinuria (urinary proteins 10 mg/dl or >10 mg/dl). Three other patients had urinary proteins < 10 mg/dl and it was considered insignificant. One of8 patients had severe proteinuria (200 mg/dl). Five of 18 patients had hematuria; 2 of these 5 patients had 2+ hematuria (6 to 10 rbc/hpf). Four patients had both proteinuria and hematuria. Severe proteinuria might have developed subsequent to thickening of glomerular basement membrane or loss of foot processes. Hematuria might have developed due to injury of glomerular capillaries.
Authors and Affiliations
Ashok Kumar Kapoor
Keywords
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