Deoxyribonucleic acid imprinted biosensor technology
Journal Title: Advanced Materials Letters - Year 2010, Vol 1, Issue 2
Abstract
In recent years, molecularly imprinted polymers (MIPs) have attracted much attention due to many of its potential applications including sensors, separation, catalysis, drug delivery and waste management. To prepare MIPs, functional monomers initially self-assemble around the template molecule via interaction between functional groups on both the template and the monomers. The selfassembled functional monomers are subsequently crosslinked in the presence of cross-linkers. Thereafter, the template molecules are removed from the MIPs, thereby leaving behind cavities/imprinted-structures that can specifically recognize and rebind with the template molecules, an analogy to the “key to lock” model. Hence, MIPs have the ability to mimic biological functions through their three-dimensional cavities of specific size, shape, and functionality for mimetic recognition of target molecules and have already shown valuable applications in the separation and recognition of glucose, cholesterol, hemoglobin, peptides, proteins, antibody, and doublestranded deoxyribonucleic acid (DNA).
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- EP ID EP129276
- DOI 10.5185/amlett.2010.8111
- Views 178
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