Dermatological paraneoplastic syndromes in gastroenterology: prediction of the inevitable or guidance to action? Part I
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 5
Abstract
This article presents information on paraneoplastic syndromes (PNS) — various pathologies and conditions that accompany and sometimes precede the onset of malignant visceral neoplasms. Although some of the PNS and neoplastic processes are not always equal, detection of PNS is an important marker associated with formation or progression of cancer. PNS definitions are still being under lively discussion in research community. Risk of PNS onset doesn’t depend on patient’s nationality, age and gender. A brief clinical description of PNS, which are mostly widespread in general therapeutic practice, is given: general, rheumatological, renal, hematological, endocrine, neurological, gastrointestinal and dermatological. Bu to date, more than 60 PNS have been described, and their list continues to grow. There is no single generally accepted PNS classification. It is proposed to classify PNS depending on the leading pathogenetic mechanism, degree of connection with malignant visceral neoplasm, dominant clinical manifestation. Concept of «dermatological PNS» is outlined according to Helen Kurt’s postulates. Manifestations of «typical» dermatological PNS in gastroenterological pathology are described. Skin changes in hereditary PNS are described (Cowden, Peitz–Jägers, Gardner syndromes), as well as dermatological manifestations of hormone-secreting tumors (ACTH-ectopic, carcinoid, glucagonoma syndromes) are characterized. Attention is paid to the pathogenesis and diagnosis of hereditary PNS, hormone-secreting tumors, their diversity and manifestation features.
Authors and Affiliations
N. B. Gubergrits, O. O. Dyadik, N. V. Bieliaieva, K. Yu. Lynevska
Keywords
Related Articles
- EP ID EP675481
- DOI 10.30978/MG-2019-5-83
- Views 132
- Downloads 0
The role of serum biomarkers in the diagnosis of nonalcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by liver steatosis and the ability to progress to more serious pathological conditions, including non-alcoholic steatohepatitis (NASH), fibrosis and ci...
The peculiarities of the effects of herbal preparations on the functional state of intestine during the treatment of patients with constipation
The analysis has been performed for the literature data as regards the medicinal herbs Operculina turpethum, Indian Gooseberry (Emblica officinalis), Cassia fistula, common licorice (Glycyrrhiza glabra), which are the co...
The relationship between the body mass index and the Firmicutes/Bacteroidetes ratio in the intestinal microbioume of the adult population of Ukraine
Objective — to investigate the difference in the composition of the main intestinal microbiota types in the adult population of Ukraine and their relationship with the body mass index (BMI). Materials and methods. Invest...
Helicobacter pylori infection and acid-related diseases against the background of metabolic-associated conditions: mechanisms of development and management
The author presents data on the role of H. pylori infection in the initiation and progression of the changes in metabolic status of patients with type 2 diabetes mellitus (DM-2), insulin resistance, obesity, cardiovascul...
The clinical-biochemical and morphological peculiarities of liver injury in patients with hematologic malignancies
Objective — to define frequency of liver infiltration by tumor cells against the background of hematologic malignancies and compare the character of pathomorphological and biochemical peculiarities of hepatotoxic reactio...