Dermatological paraneoplastic syndromes in gastroenterology: prediction of the inevitable or guidance to action? Part I
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 5
Abstract
This article presents information on paraneoplastic syndromes (PNS) — various pathologies and conditions that accompany and sometimes precede the onset of malignant visceral neoplasms. Although some of the PNS and neoplastic processes are not always equal, detection of PNS is an important marker associated with formation or progression of cancer. PNS definitions are still being under lively discussion in research community. Risk of PNS onset doesn’t depend on patient’s nationality, age and gender. A brief clinical description of PNS, which are mostly widespread in general therapeutic practice, is given: general, rheumatological, renal, hematological, endocrine, neurological, gastrointestinal and dermatological. Bu to date, more than 60 PNS have been described, and their list continues to grow. There is no single generally accepted PNS classification. It is proposed to classify PNS depending on the leading pathogenetic mechanism, degree of connection with malignant visceral neoplasm, dominant clinical manifestation. Concept of «dermatological PNS» is outlined according to Helen Kurt’s postulates. Manifestations of «typical» dermatological PNS in gastroenterological pathology are described. Skin changes in hereditary PNS are described (Cowden, Peitz–Jägers, Gardner syndromes), as well as dermatological manifestations of hormone-secreting tumors (ACTH-ectopic, carcinoid, glucagonoma syndromes) are characterized. Attention is paid to the pathogenesis and diagnosis of hereditary PNS, hormone-secreting tumors, their diversity and manifestation features.
Authors and Affiliations
N. B. Gubergrits, O. O. Dyadik, N. V. Bieliaieva, K. Yu. Lynevska
Keywords
Related Articles
- EP ID EP675481
- DOI 10.30978/MG-2019-5-83
- Views 108
- Downloads 0
The relationship of serum inflammatory markers with metabolic disorders at the non-alcoholic fatty liver disease
Objective — to study the serum levels of proinflammatory markers and determine their role in the formation of metabolic disorders in patients with non-alcoholic fatty liver disease (NAFLD). Materials and methods. Examin...
NSAID induced gastropathy in the practice of a family doctor
Nonsteroidal anti-inflammatory drugs (NSAID) are the mostly often prescribed agent for the treatment of various pathologies. However their application associated with the development of side effects, and NSAID induced ga...
The diseases of the upper part of gastrointestinal tract: risk factors
The authors present results of clinical and statistic investigation devoted to the study on influence of various risk factors (age, sex, pernicious habits, dietetic regimen, occupational hazards etc.) on the development...
Functional intestinal symptoms in patients with inflammatory bowel disease: recommendations of the American Gastroenterological Association (2019)
The paper presents overview of the latest recommendations of the American Gastroenterological Association on the management of patients with functional intestinal symptoms (FIS). It was noted that the prevalence of irrit...
Peculiarities of microbic landscape at NSAID-induced gastropathy in patients with diabetes mellitus
Objective — to investigate the frequency and nature of microbial lesions of the mucous membrane of the upper gastrointestinal tract in patients with NSAID-induced gastropathy against the background of diabetes mellitus (...