Design and In-vitro Evaluation of Fast Dissolving tablet of Urapidil Hydrochloride
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2015, Vol 3, Issue 4
Abstract
An attempt has taken to formulate Urapidil Fast Dissolving tablet using various super disintegrants such as Cross povidone, Cross carmellose sodium and Sodium starch glycolate employing direct compression technique. Mannitol was added in the formulation to promote the cooling sensation of the prepared tablet. The physiochemical and micromeritic parameter were evaluated and all the formulations showed satisfactory result. The release characteristic was evaluated by dissolution study. Result showed the formulation containing Cross povidone exhibited faster release than all formulation. Drug polymer interaction study was conducted by FTIR and DSC. No such major interaction was found for the formulation
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