Abstract

Nitrendipine is an antihypertensive agent, classified under calcium channel blocker shows marked vasodilator action. The aim of the present work is to design and evaluate a matrix-type transdermal formulation containing nitrendipine with different ratios of hydrophilic (Hydroxy propyl methyl cellulose K-15) and hydrophobic polymer (eudragit RS 100) combinations plasticized with glycerine by the solvent evaporation technique. In the current study, effect of permeation enhancers include oleic acid, dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF) is studied. FTIR studies were conducted to know the interference of the polymers in formulation and also physicochemical characteristics were studied for all prepared patches these include physical appearance, thickness, folding endurance, weight variation, percentage moisture loss, percentage moisture absorption, water vapour transmission, drug content and tensile strength. In vitro drug release studies were carried out with Franz diffusion cell using pH 7.4 phosphate buffer solution. Formulation patch F6 containing hydroxypropylmethylcellulose k15 (500mg) has given drug release of99.626at48hrs. Thus, Formulation F6 was optimized as a best formulation. Final formulation was subjected to kinetic models such as zero order, first order, Higuchi and Korsmeyer-Peppas models. All the evalutation studies were given satisfied results. Therefore, it was concluded that Transdermal patches were prepared were found to be satisfactory. And also it was found that developed nitrendipine transdermal patch has considerable action of control drug release in blood stream.

Authors and Affiliations