DESIGN AND IN VITRO EVALUTION OF SUSTAINED RELEASE FILM COATED TABLETS OF VERAPAMIL HYDROCHLORIDE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
An attempt was made to formulate the sustained release tablet of verapamil hydrochloride by using the wet granulation method for the treatment of hypertension. In the present formulation the tablets releases the loading dose by immediate drug release and maintenance dose up to 15 hours by extended release. The drug excipient compatability study was carried out with HPLC method and there was no interaction found. Immediate release fraction was formulated by using croscarmellose sodium as a disintegrating agent and extended release fraction was formulated by using Hypromellose E4 as a rate controlling polymer. The granules were evaluated for pre and post compressional character which showed satisfactory results. In vitro dissolution study was carried out for 15 hrs using USP dissolution apparatus type II with 0.1 N HCl and 7.4 pH phosphate buffer as dissolution medium. From the dissolution profile, F2 & F3 values were calculated which were within the specification. Stability study was carried out for the optimized formulation at 40°C/75% RH for 1 month, the result showed that there was no significant change in physical and chemical parameter of the tablet.
Authors and Affiliations
BS Venkateswarlu, B Jaykar, Pasupathi A, R Margret Chandira, Palanisamy P
Keywords
Related Articles
- EP ID EP33019
- DOI -
- Views 449
- Downloads 0
FORMULATION AND EVALUATION OF CAPTOPRIL MICROENCAPSULES: A SUSTAINED RELEASE APPROACH
The aim of the present study is to formulate and evaluate Captopril micro-encapsules. Microspheres and micropellets of captopril prepared with different polymers through the techniques of microencapsulation were found...
Development and validation of new RP-HPLC method for simultaneous estimation of drug Thiocolchicoside and Etodolac in tablet dosage form
A simple, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Thiocolchicoside and Etodolac was developed and validated according to ICH guidelines. The quantifica...
A Review on Water Purification Techniques
The existence of human beings depends on the availability of water. Accessibility to safe drinking water is very less in the world. With the advent of technology various purification techniques of water are available f...
Drying of agriculture products using hot air oven and microwave method
Drying, an ancient process to preserve foodstuffs. Hot air drying may lead to produce dried products with more than one year shelf life. However the quality of oven dried products is less than the origin products. The a...
Spectrometric and RP-HPLC method for the determination of transresveratrol in vegetarian formulation
Estimation of Trans-resveratrol was achieved by Spectrometric method. After considering the solubility studies, distilled water was selected as a solvent for the UV analysis. Trans-resveratrol 10μg/ml solution was prep...