Design and Optimizing of Metformin and 5-Fluorouracil Co-Loaded Nano Spheres by Box-Behnken Experimental Design for the Treatment of Colorectal Cancer
Journal Title: International Journal of Current Science Research and Review - Year 2024, Vol 7, Issue 07
Abstract
Aim and objective of the study was to design and optimize metformin and 5-Fluorouracil drug molecules co-loaded with chitosan biodegradable polymer Nano-spheres for effectively targeting colorectal cancer cells in chemically induced colorectal cancer models. The metformin and 5- fluorouracil loaded chitosan nanoparticles were formulated by ionotropic crosslinking method. Experimental design consisted of three independent variables: chitosan, tripolyphosphate and stirring speed and three dependent variables: particle size, entrapment efficiency and drug release using Box-Behnken experimental design. Response surface modelling and the ability to fit to the model were evaluated with Design-Expert® software (Version 12). The optimized formulation by the design software indicated 1.33% of chitosan, 0.715 % of TPP at a Stirring speed of 3383 rpm is recommend to achieve a desirability value of 0.813 to have an acceptable range of 0.8 to 1, suggesting that the formulation quality is acceptable and excellent.
Authors and Affiliations
Bharathi Priya K, Kulathuran Pillai K, Nalini CN, Ubaidulla Udhumansha,
Keywords
Related Articles
- EP ID EP739988
- DOI 10.47191/ijcsrr/V7-i7-16
- Views 42
- Downloads 0
Proposed Business Strategy to Increase Competitiveness for Chemical Textile Company: A Case Study of CV XYZ
CV XYZ, a chemical textile company, has faced fluctuating profitability, requiring a robust business strategy to improve financial performance and market position. This research identifies the root causes of these challe...
The Role of Nu-Cyber and Muhammadiyah-Cyber Role in Increasing Cyber-Extremism in the East Java
Penetration of the increasingly widespread use of the internet in society has inspired extremists to use cyberspace as a new arena for jihad. It is in this context that NU and Muhammadiyah as the largest Islamic organiza...
Quality Control and Quality Assurance of The BPK’s Audit of Regional Government Financial Statements Fiscal Year 2022 (Case Study at AKN VI)
The Audit Board of the Republic of Indonesia (BPK) is a state institution mandated to audit management and accountability of state finances. One of the objects of Audit’s BPK is the Financial Statements of Regional Gover...
Brand Loyalty as a Catalyst for Growth: Leveraging Innovative Brand Experience to Enhance Market Success for a Small Clothing Brand
This research entitled “Brand Loyalty as a Catalyst for Growth: Leveraging Brand Experience to Enhance Market Success for Small Clothing Brands in Triple Two Reworks” aims to identify strategies that can increase brand l...
Hyperparameter Tuning of Random Forest Algorithm for Diabetes Classification
This study aims to optimize the hyperparameters of the Random Forest model in diabetes classification using the Pima Indian Diabetes dataset, given the importance of early diabetes diagnosis to mitigate serious health im...