DESIGN, FORMULATION AND IN VITRO EVALUATION OF TELMISARTAN SUSTAINED RELEASE TABLETS
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2018, Vol 7, Issue 6
Abstract
Objective: The purpose of present research work is to develop the sustained release formulation for Telmisartan using 32 factorial design. Telmisartan an Antihypertensive agent, nonpeptide angiotensin-II receptor (type AT1) antagonist and BCS class-II agent. Methods: Sustained Release tablet formulations of Telmisartan were prepared using different quantities of HPMCK100M and Xanthan Gum in combinations by direct compression technique. The concentration of Polymers, HPMCK100M and Xanthan gum required to achieve the drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug release (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables. Nine formulations were prepared and are evaluated for various pharmacopoeial tests. Results: The results reveals that all formulations were found to be with in the pharmacopoeial limits and In vitro drug release profiles of all formulations were fitted in to various Kinetic models. The statistical parameters like intercept, slope & correlation coefficient were calculated. Polynomial equations were developed for dependent variables. Validity of developed polynomial equations were checked by designing 2 check point formulations (C1, C2). Conclusion: According to SUPAC guidelines formulation (F5) containing combination of 15% HPMCK100M and 15% Xanthan gum, is the most identical formulation (similarity factor f2= 90.863, dissimilarity factor f1= 1.665 & No significant difference, t= 0.03379) to marketed product (TELVAS). Best Formulation F5 follows First order, Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion Anomalous Transport. (n= 0.828).
Authors and Affiliations
Raghavendra Kumar Gunda et al. , Prasada Rao Manchineni
Keywords
Related Articles
- EP ID EP537021
- DOI -
- Views 154
- Downloads 0
RETROSPECTIVE STUDY OF COMPARATIVE EFFECTIVENESS OF TWO ARTESUNATE COMBINATION DRUG REGIMENS IN UNCOMPLICATED FALCIPARUM MALARIA IN CHILDREN
Background: Malaria is a major cause of morbidity and mortality in children in developing world. Successful treatment and avoidance of resistance development to anti-malarial drugs in endemic areas are important current...
OPTIMIZATION AND CHARACTERIZATION OF STAVUDINE CONTROLLED RELEASE TABLETS
Objective: The objective of the study is to develop controlled release tablets of stavudine. Methods: Wet granulation technique was adopted for the preparation of all these formulations. The developed tablets were evalua...
FORMULATION INVITRO EVALUATION OF FAST DISSOLVING TABLETS OF LEVOCETIRIZINE DIHYDROCHLORIDE BY DIRECT COMPRESSION METHOD
The demand for fast dissolving tablets has been growing during the last decade, especially for elderly and children who have swallowing difficulties. In the present work, fast dissolving tablets of Levocetirizine dihydro...
ALTERATIONS IN BMI, BLOOD PRESSURE EXERCISE WITH ONE TO THREE TIMES PER WEEK WITH SOMEONE WHO DO NOT EXERCISE IN STUDENTS OF TEHRAN MEDICAL BRANCH OF AZAD UNIVERSITY, 2011
Background and Aim: These days, no one can dispute the fact that, in addition to positively affecting physical health, exercising also has the same effect on people’s mental health. Given that young male and female unive...
THE IMPACT OF THE KNOWLEDGE AND ATTITUDE OF RURAL INSURED ON THE FAMILY PHYSICIAN PROGRAM IN BUSHEHR PROVINCE IN 2016
Introduction: Health and safety are considered as the basic rights of each individual in the community and the state is obliged to provide it equally for members of the community. From the perspective of the World Health...