Abstract

The demand for fast disintegrating tablets has been growing, during the last decade especially for geriatric and paediatric patients because of swallowing difficulties. Urapidil is a new generation of sympatholytic antihypertensive (class-II) available in European market. Hence in present work an attempt has been made to formulate fast dissolving tablets of urapidil by direct compression technique using various concentration of Superdisintegrants like Cross carmellose sodium (Ac-Di-Sol), Polyplasdone R-XL and Sodium starch glycolate (SSG). The formulated tablets were evaluated for Crushing strength, Friability, Thickness, Diameter, Weight variation, Drug content, Wetting time, Water absorption ratio, Disintegration time and Percentage of drug release. All formulations showed satisfactory result. Among them formulation AD3 containing 3% of Ac-Di-Sol exhibited complete release within 1 hour and disintegration time within 10 second. Accelerated stability study indicated no significant difference in assay and crushing strength. There was no chemical interaction between the drug and excipients during FT-IR study and DSC study considered in the present investigation.

Authors and Affiliations