Determinants of hemorrhagic risk during acenocoumarol treatment
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2012, Vol 4, Issue 1
Abstract
Objective: to determine the frequency of haemorrhage occurrence in the analysed batch; to establish the relation between the hemorrhagic risk and the presence of supratherapeutic INR; to assess the concomitant therapy’s impact on the haemorrhage risk’; to study the impact of the age and sex on the hemorrhagic risk; to assess the relation between the polymorphisms of the CYP2C9 & VKORC1 genes and the occurrence of hemorrhages. Material and Methods: The study included 223 patients (110 females (49.3%) and 113 males (50.7%)) who were treated with acenocoumarol for one or several of the following clinic situations: 1. deep vein thrombosis (DVT) of the lower limb ± pulmonary thromboembolism; 2. persistent or permanent atrial fibrillation (AF) ± pulmonary thromboembolism. Results: Bleeding complications were registered in 11 patients (4.9%). The presence of a supratherapeutic INR increases the risk of bleeding complications by 3.1 times. Conclusion: our study shows that only the supratherapeutic INR was correlated with the occurrence of haemorrhages.
Authors and Affiliations
Florentina Militaru, Sorin Crişan, Ştefan Vesa, Adrian Trifa, Valentin Militaru, Anca Buzoianu
Keywords
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