Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design
Journal Title: The AAPS Journal - Year 2016, Vol 18, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-016-9892-3) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Katie F. Maass, Chethana Kulkarni, Alison M. Betts, K. Dane Wittrup
Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids
The online version of this article (doi:10.1208/s12248-015-9732-x) contains supplementary material, which is available to authorized users.
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Overdose of γ-hydroxybutyrate (GHB) can result in severe respiratory depression. Monocarboxylate transporter (MCT) inhibitors, including l -lactate, increase GHB clearance and represent a potential treatment for...
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In the present study, the applicability of fine particle ethylcellulose (FPEC) to produce matrix tablets by a wet granulation technique was evaluated. The effect of various formulation and process variables, such as FPEC...
Nanosystems for simultaneous imaging and drug delivery to T cells
The T-cell response defines the pathogenesis of many common chronic disease states, including diabetes, rheumatoid arthritis, and transplant rejection. Therefore, a diagnostic strategy that visualizes this response can p...