Development and in Vitro Evaluation of Ambroxol Hydrochloride Niosomes Using Thin Film Hydration Method
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Niosomes (non-ionic surfactant vesicles) are microscopic lamellar structures obtained on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. The main objective of research work provides sustained release of drug, maximum therapeutic effect for a long period of time, also decreases the frequency of dosing. Ambroxol HCl used as model drug, used in pulmonary bronchitis. Therefore formulation of Ambroxol HCl as niosomes would provide advantages of sustained release dosage forms. Niosome vesicles were prepared using thin layer evaporation method and were physico-chemically characterized. Ambroxol HCl was formulated with different non ionic surfactants such as Span20, Span60, Tween60 and Tween80 and Dicetyl phosphate (DCP) as charge inducing agent. The average diameter of the vesicles was found to be 4.16. The in vitro diffusion studies suggest that higher entrapment efficiency was found with slow release. Niosomes prepared using Span 20 (F10, F11, and F12) shown better entrapment than that was prepared using Span60 (F1, F2, F3). Tween60 (F7, F8, F9) also shown better entrapment efficiency than Tween 80 (F4, F5, F6).Tween 60 shown better entrapment than other formulations.
Authors and Affiliations
Parika Singh*, Mrs. Nitya Shanti, Basant Sharma, Neha krishnarth
Keywords
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- EP ID EP384505
- DOI 10.9790/3008-1103021018
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