Tailor Made Phospholipid Based Curcumin Phytosomes: Fabrication, Characterization and Ex-Vivo Permeation
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Curcumin (CUR), a highly lipophilic molecule has wide range of pharmacological activities. Nevertheless its limited aqueous solubility and extensive pre-systemic metabolism confine its bioavailability. CUR phytosomes were prepared by simple method and were evaluated in comparison to commercial patent product by DSC, FTIR, TEM, SEM as well as in vitro drug release profile in different dissolution media. Furthermore, a new ex-vivo experimental design utilizing non everted sac model was held out to study the permeability behavior of prepared phytosomes. Results revealed that prepared phytosomes were similar to commercial product in all physicochemical properties. They were spherical; self-closednano-sized structure with good physical stability. DSC and FTIR studies showed a strong complex formation between CUR and phospholipid. Change in surfactant concentration had no effect on the dissolution profile for both CURphytosomal powders. Ex-vivo permeation and mucosal uptake studies across rat intestine revealed a good similarity. Complexation of CUR with phospholipid leading to 4 times enhancement in permeation compared with drug suspension. Lipophilic nature of CUR could be the reason for drug entrapment inside the intestinal mucosal cells with limited permeation.The prepared phytosomes could be successfully tailored as a promising and effective formulation for CUR delivery.
Authors and Affiliations
Ahmed N. Allam1, Ibrahim A. Komeil, Ossama Y. Abdallah1
Keywords
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