DEVELOPMENT AND VALIDATION OF ANALYTICAL TECHNIQUE FOR NON STEROIDAL ANTI INFLAMMATORY DRUGS (NSAIDs) BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)
Journal Title: International Journal of Pharmaceutical, Biological and Chemical Sciences (IJPBCS) - Year 2012, Vol 1, Issue 1
Abstract
Drug analysis plays an important role in the development of drugs, their manufacture and therapeutic use. Pharmaceutical industries rely upon quantitative chemical analysis to ensure that the raw material used and final products obtained meet the required specifications. The number of drugs and drug formulations introduced into the market has been increasing at an alarming rate. These drugs or formulations may be either new entities or partial structural modifications of the existing ones or novel dosage forms (controlled/ sustained release formulations) or multi component dosage forms. Very often, there is a time lag from the date of introduction of a drug into the market to the date of its inclusion in pharmacopoeias. This happens because of the possible uncertainties in the continuous and wider usage of these drugs, reports of new toxicities (resulting in their withdrawal from the market), development of patient resistance and introduction of better drugs by competitors. Under these conditions, standards and analytical procedures for these drugs may not available in pharmacopoeias. It becomes necessary, therefore, to develop newer analytical methods for such drugs. Considering all these views some drug formulations from Non Steroidal Anti Inflammatory Drugs (NSAIDs) were selected for the present study.
Authors and Affiliations
Santosh Kumar. M*, Venkateshwar Rao. J
Keywords
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- EP ID EP98147
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