DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND NIFEDIPINE IN SYNTHETIC MIXTURE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 5
Abstract
This method deals with the simultaneous determination of the Telmisartan and Nifedipine in the synthetic mixture. This method is simple, precise, accurate and economical. The work was carried out on Shimadzu model 1800 (Japan) double beam UV visible spectrophotometer with spectral width of 2 nm, wavelength accuracy of 0.5 nm and a pair of 10 mm matched quartz cell was used to measure absorbance of all the solutions. Distilled methanol was used as a solvent. The linearity range for both the drugs Telmisartan and Nifedipine were 1-18µg/ml and 2-20µg/ml. The Telmisartan has absorbance maxima at 297.2 nm and Nifedipine has absorbance maxima at 235.5 nm in distilled methanol. The mean recovery was 100.7±0.64 for Telmisartan and 100.3±0.77 for Nifedipine respectively. The results of analysis have been validated statically and by recovery studies. This simple and precise method can be used for routine analysis of both the drugs in quality control laboratories.
Authors and Affiliations
Modi Dixita , Paresh Patel
Keywords
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- EP ID EP143841
- DOI 10.7897/2230-8407.07542
- Views 78
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