Development and validation of UV spectrophotometric method for quantitative estimation of nitroglycerin in pharmaceutical dosage form
Journal Title: International Current Pharmaceutical Journal - Year 2011, Vol 1, Issue 1
Abstract
A new, simple, specific, sensitive, rapid and economical procedure has been developed for determination of Nitroglycerin in its dosage form. The objective of this validation of an analytical procedure is to demonstrate that the drug Nitroglycerin is suitable for its intended purpose. The analytical method development recommends the quality, purity and specificity of the drug Nitroglycerin tablet form during the manufacturing process and hence the standard of the drug may not vary, which produce the desirable therapeutic effect. The method is based on the ultraviolet absorbance maxima of the above drug at 210nm. The drug obeyed Beer's law in the concentration range of 15μg/ml in methanol. The proposed methods were successfully applied for the determination of drug in commercial tablet preparations. The results of the analysis have been validated statistically and by recovery studies.
Authors and Affiliations
Rajia Nijhu, Dewan Akhter, Yeakuty Jhanker
Keywords
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- EP ID EP140285
- DOI http://dx.doi.org/10.3329/icpj.v1i1.9217
- Views 104
- Downloads 0
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Development and validation of UV spectrophotometric method for quantitative estimation of nitroglycerin in pharmaceutical dosage form
A new, simple, specific, sensitive, rapid and economical procedure has been developed for determination of Nitroglycerin in its dosage form. The objective of this validation of an analytical procedure is to demonstrate t...