DEVELOPMENT OF HYDROPHILIC MATRIX TABLET OF CARBAMAZEPINE USING 33 FULL FACTORIAL EXPERIMENTAL DESIGNS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The study aims at developing the hydrophilic matrix tablet of carbamazepine (CBZ) using an optimization technique. The purpose of the study was to develop the hydrophilic matrix dosage form using the combination of different viscosity grades of hydroxypropyl methylcellulose (HPMC) to get the release within the desired target dissolution profile (TDP).Methods: A full factorial design was employed to develop once a day matrix tablet using hydrophilic matrix polymers like HPMC K4M (X1), HPMC K15M (X2) and HPMC K100M (X3) as independent variables and the percent drug release at 1h (Y1), 8h (Y2) and 20h (Y3) was considered as dependent variables. The optimization and the design space were obtained using response surface methodology and multiple response optimization using the polynomial equation.Results: The result indicates that concentration of all the three polymers plays an important role in the release of the drug for 24h. The formulated tablets have good physical properties and the optimized formulation prepared using design space showed the release within the target dissolution profile and followed zero order release pattern.Conclusion: The results demonstrated that design of an experiment can be used to develop hydrophilic matrix dosage form with the desired drug release properties.Â
Authors and Affiliations
Shashikant Barhate, Maria Husain
Keywords
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