Development of new RP-HPLC method for the simultaneous estimation of Satranidazole and Oflaxacin pharmaceutical dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 5
Abstract
A simple and selective LC method is described for the determination of Satranidazole and Ofloxacin in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 50 volumes of triethylamine and 50 volumes of Acetonitrile with detection of 270 nm. Linearity was observed in the range 100-300 µg/ml for Satranidazole (r2 =0.997) and 150-450 µg /ml for Ofloxacin (r2 =0.998) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. It is most precise method which is indicated by the results. The method was found to be precise which is indicated by the repeatability analysis, with < 2 showing %RSD. The statistical data thus obtained proves validity of the methods and can be used for pharmaceutical dosage form routine analysis.
Authors and Affiliations
M. Fatima Rose, Rajyalakshmi Peruboina, Hassan Eaisa Mohamed Hamid, P. Parthipan
Keywords
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