Development of spectrophotometric method for simultaneous estimation of diclofenac sodium and papaverine hydrochloride in tablets based on simultaneous equation method
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2012, Vol 25, Issue 2
Abstract
A simple, rapid, accurate and precise spectrophotometric method for simultaneous estimation of diclofenac sodium and papaverine hydrochloride in combined tablet and the dissolution media used in the release studies has been developed. It employs formation and solving of simultaneous equation using two analytical wavelengths corresponding to diclofenac sodium and papaverine hydrochloride in the dissolution medium. This method obeys Beer’s Law in the employed concentration ranges of 2.5-25 µg/mL for two active substances. The method was validated.
Authors and Affiliations
Regina Kasperek, Łukasz Zimmer, Katarzyna Świąder, Piotr Belniak, Ewa Poleszak
Keywords
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