Diagnostic Accuracy of mammography Versus Distribution of p63 in Fine Needle Aspiration of Breast Malignancies
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Mammography is used as a screening tool for detection of carcinoma breast above the age of 35 years. FNAC is an established technique for the detection of breast malignancies. Myoepithelial cells are important marker for identification of breast carcinoma. p63 immunostaining has gained wide popularity for identification of myoepithelial cells. We planned this study to compare the effectiveness of mammography and p63 in detection of carcinoma breast.Total 50 cases were included in the study. Clinical features, mammography, FNAC and p63 immunostaining were performed. Results of mammography and p63 immunostaining were compared with the FNAC diagnosis. These were analysed statistically using chi-square test.Infiltrating ductal carcinoma (IDC) was found in 54% of cases. 96% IDC cases were p63 negative when stained immunocytologically. Diagnostic accuracy of p63 was significantly higher than mammography for diagnosing breast malignancies (p value <0.05).p63 can be a good adjunct to FNAC in diagnosis of breast malignancies. However, the cut off value of percentage of p63 positive cells needs to be standardised.
Authors and Affiliations
Dr Neha Tyagi, Dr Charanjeet Ahluwalia, Dr Sachin Kolte, Dr Akansha, Dr Himani Bhankar
Keywords
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- EP ID EP592508
- DOI 10.9790/0853-1602086064.
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