Diagnostic assessment of liver enzymes in blood profiles from dairy cows

Journal Title: Revista MVZ Cordoba - Year 2013, Vol 18, Issue 2

Abstract

Objective. The aim of this study was to establish the association, sensibility (Se) and specificity (Sp) of the plasmatic activity of glutamate dehydrogenase (GDH, EC: 1.4.1.3), aspartate aminotransferase (AST, EC: 2.6.1.1) and g-glutamil transpeptidase (GGT, EC: 2.3.2.2) as liver damage markers in blood profiles of dairy cows. Materials and methods. The records of the plasma activity for GDH, AST and GGT obtained from blood profiles taken from 1566 cows from 112 dairy herds. The association between enzymatic activity, area below the curve (ABC), and Se and Sp using a ROC curve were determined, considering liver damage when GDH >30 U/L or GGT >39 U/L. Results. The AST was more likely associated to GDH (r=0.55) than to GGT (r=0.44). AST also had a higher ABC (p=0.01) when using GDH >30 U/L as an indicator of liver damage. The correlation between AST and GGT was of r=0.42. AST Se to detect liver damage with a cut-off level of >150 U/L was lower than the Se of GGT. The critical point for maximum Se and Sp of the ROC curve was obtained with AST>110 U/L and an increase in the diagnostic concordance with GDH (Kappa>0.300), was obtained using this value. Conclusions. Plasma activity of AST is more associated to GDH than to GGT in dairy cows. The cut-off level of plasma activity of AST for liver damage prediction in dairy cows would be >110 U/L.

Authors and Affiliations

Mirela Noro, Ph. D *| Universidade Federal do Pampa, UNIPAMPA, Curso Medicina Veterinaria. Uruguaiana, Brasil.Correspondencia: mirelanoro@gmail.com, Pía Cid T, Esp| Universidad Austral de Chile, UACh, Instituto Ciencias Clínicas Veterinarias. Casilla 567, Valdivia, Chile., Catalina Wagemann F, M. Sc| Universidad Austral de Chile, UACh, Instituto Ciencias Clínicas Veterinarias. Casilla 567, Valdivia, Chile., Verónica Arnés V, Tec Med| Universidad Austral de Chile, UACh, Instituto Ciencias Clínicas Veterinarias. Casilla 567, Valdivia, Chile., Fernando Wittwer M, M. Sc| Universidad Austral de Chile, UACh, Instituto Ciencias Clínicas Veterinarias. Casilla 567, Valdivia, Chile.

Keywords

Related Articles

Reproductive performance of bocachico Prochilodus magdalenae induced twice in the same year

Objective. To evaluate the reproductive performance of hormonally induced bocachico with carp pituitary extract (CPE) twice in the same year. Materials and methods. 23 females, in their final maturation phase, were induc...

GROWTH FACTORS IN THE FOLLICULAR DEVELOPMENT, EMBRYONIC EARLY AND IMPLANTATION. IMPLICATIONS IN THE PRODUCTION OF BOVINE EMBRYOS

The review describes the role the growth factors on follicular development, early embryonic, implantation and their importance in the production of bovine embryos. It describes, growth factors its important roles in key...

Parasites in dairy cattle farms in southern Brazil

Objective. The aim of this study was to investigate the relation among type and size of the farms related to the management of production and especially the presence and control of parasites. Materials and methods. To ac...

Lipofundin 20% induces hepatic lipid peroxidation in New Zealand white rabbits

Objective. The aim of the present work was to evaluate the effects of Lipofundin 20% on lipid peroxidation markers in the liver of New Zealand white rabbits. Materials and methods. The animals were treated with an intrav...

Occurrence and identification of yeasts in dogs external ear canal with and without otitis

To analyze the presence of yeast in the external ear canal of 116 dogs with and without a diagnosis of otitis from veterinary clinic in the Chapecó city, Santa Catarina, Brazil, and to examine the secretion of the protei...

Download PDF file
  • EP ID EP3308
  • DOI -
  • Views 386
  • Downloads 16

How To Cite

Ph. D *, Esp, M. Sc, Tec Med, M. Sc (2013). Diagnostic assessment of liver enzymes in blood profiles from dairy cows. Revista MVZ Cordoba, 18(2), 3474-3479. https://europub.co.uk/articles/-A-3308