Diagnostic Performance of Histidine Rich Protein-2 and Parasite Lactate Dehydrogenase Based Rapid Diagnostic Tests for Detection of Malaria Parasites
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
AIM: Malaria remains as a life-threatening parasitic disease in Indian scenario and poses a great diagnostic challenge. RDTs have emerged as an alternative diagnostic tool, providing a giant leap in malaria diagnosis curtailing the disadvantages of microscopy in rural endemic areas. This study aims to assess the performance of two commercially available bivalent RDTs based on HRP-2 and pLDH with microscopy of blood films as diagnostic tool for malaria detection. METHODS:Peripheral blood was taken from a total of 5,456 patients, presenting with fever, chills and rigor with profuse sweating and the JSB stained smears were examined for malaria parasites. Simultaneously, venous blood was tested by two different commercially available RDTs,AlereTrueline Malaria Ag P.f/Pan and Advantage Malcard Malaria Ag P.f/Pan. RESULT: A total of 52 samples were found to be positive for malaria parasites by smear microscopy. Advantage Malcard and AlereTrueline picked up all falciparum malaria cases. Advantage Malcard was unable to detect only one case of non-falciparum malaria while AlereTrueline missed five of them. The analysis of results revealed sensitivity for Advantage Mal card (98.08%) to be higher than AlereTrueline (90.38%). CONCLUSION: RDTs would be a better alternative diagnostic tool for malaria detection, especially for remote areas where smear microscopy is hard to establish. An ideal RDT with good diagnostic performances will play a pivotal role in speedy identification of malaria, in all levels of health care in near future.
Authors and Affiliations
T. Susitha, M. Sudha, R. Murali
Keywords
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- EP ID EP381068
- DOI 10.9790/0853-1708061215.
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