Diagnostic Role of Anti PGL-1 Antibody, Antigen 85-C and IP-10 (Interferon Gamma Inducible Protein) in Pediatric Leprosy
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 9
Abstract
Introduction: Early cases of pediatric leprosy are difficult to diagnose when characteristic skin lesions are not present and where Acid Fast Bacilli are difficult to detect. It is important to detect these early cases of leprosy in children to reduce the rate of transmission and prevent disability as emphasized by Who Global Leprosy Strategy 2016-2020. Our study analyzed the detection of Anti- 85C antibody, Anti PGL-1 antibody and Human interferon inducible protein (IP-10) using ELISA (Enzyme Linked Immunosorbent Assay) in early pediatric leprosy cases. Material and Methods. A prospective study was conducted in 30 untreated early paediatric leprosy cases equal to or less than 16 years. Their clinical profile, slit skin smear examination and serological test results using ELISA were studied. Result: Serological testing results were compared between cases and controls. The outcome was significant (P value <0.005) for all the three serological markers. Sensitivity and specificity of anti-85C was 76.67% and 90%, that for anti PGL-1 was 46.67% and 90% while that for IP-10 was 43.33% and 93.33% respectively. Sensitivity of Ag85C was higher than PGL-1 and IP-10. Only 30% cases were slit skin smear positive. Conclusion: Anti PGL-1 antibody, anti-85C antibody and IP-10 based ELISA on serum can be useful research tool in confirming early diagnosis of leprosy in cases where slit skin smears for AFB is negative and skin biopsy is not feasible.
Authors and Affiliations
Dayal R, Kamal R, Mishra C, Singh S P, Kumar N, Joshi B, Mohanty K. K
Keywords
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