Dietary Compo pounds As Anti-cancer Agents:<br /> A Preliminary Evaluation of Ion Channels And Membrane<br /> Excitability As Possible Target Mechanisms
Journal Title: Türk Biyokimya Dergisi/Turkish Journal of Biochemistry - Year 2006, Vol 31, Issue 2
Abstract
Although a variety of natural, dietary compounds have been suggested to have anti-cancer properties, their modes of action are not well understood. In this article, we adopt membrane excitability and associated ion channel expression / activity as possible target mechanisms. Our previous work has shown that in a number of major human metastatic carcinomas (breast, prostate, small-cell lu lung cancers) functional voltage-gated Na+ channels are upregulated concomitantly with down-regulation of voltage-gated K+ channels. Such characteristics would render the cells’ membranes potentially ‘excitable’, in line with such cells’ ‘hyperactive’ behaviour. We call this the “cellular excitability” (“CELEX”) hypothesis of cancer progression. Here, we evaluate a number of natural anti-cancer compounds from the point of view of their possible effects mainly upon VGSC, and to a lesser extent K+ channel expression / activity, in accordance with the hypothesis. The compounds evaluated include phytochemicals (resveratrol, curcumin, capsaicin, genistein and ginseng), those of marine origin (omega-3 polyunsaturated fatty acids) and minerals (zinc). The review does not intend be exhaustive and the emphasis is upon demonstrating sufficient detail in the examples given to establish ‘proof of princip iple’. It is concluded (1) that many dietary compounds, for which there is evidence for anti-cancer effects, work broadly in accordance with the CELEX hypothesis and (2) that this is a viable, futuristic field of study, but the modes of action of dietary compounds and natural products n s need to be evaluated much more systematically.
Authors and Affiliations
Mustafa Djamgoz, Banu Isbilen
Keywords
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