Differences and Relationships between Morphometric Parameters and Zinc Content in Nonhyperplastic and Hyperplastic Prostate Glands
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 8, Issue 8
Abstract
Aims: To clarify the changes in morphometric parameters and contents of zinc (Zn) and in the relationship between these characteristics in normal and hyperplastic human prostates, a quantitative morphometry and energy-dispersive X-ray fluorescence analysis was performed. Methodology: Samples of the human prostate of mass under 30 g were obtained from randomly selected autopsy specimens of 35 men (European-Caucasian aged 40-87 years) who died mainly from trauma. All prostate glands were divided into two portions, each with an anterior-posterior cross-section: one tissue portion was reviewed by an anatomical pathologist while the other was used for the Zn mass fraction measurement. After preliminary histological investigation the subjects were divided into a control group (n=24) and a benign prostatic hyperplasia (BPH) group (n=11). The mean percent volume of the stroma (S), glandular epithelium (E), glandular lumen (L) and glandular component (GC=E+L) were determined, and the mean ratios of percent volumes (S/E, S/GC, and E/L) were calculated for each prostate specimen. Results: Increases in E (33.6% vs 26.7%) and GC (52.3% vs 44.4%) and also a decrease in S (47.7% vs 55.6%), S/E ratio (1.53 vs 2.31) and S/GC ratio (0.97 vs 1.40) were observed, when values for Zn mass fraction in the earliest stage of BPH were compared with normality. A significant positive correlation between Zn and L (r = 0.65, P0.001) and between Zn and GC (r = 0.45, P0.05) and also a negative correlation between Zn and S (r = - 0.45, P0.05), between Zn and E/L ratio (r = - 0.63, P0.001), and between Zn and S/GC ratio (r = - 0.42, P0.05) was seen in histologically normal prostate tissue. A negative correlation between Zn and S and a positive correlation between Zn and L disappeared in the earliest stage of hyperplastic change. It means that a homeostatic control of Zn level in the histological structures of prostate tissue was partially destroyed. Conclusion: For the first time it was quantitatively shown that BPH begins from the excessive proliferation of the glandular epithelium and that the Zn redistribution in the histological structures of prostate tissue is a pathogenetic factor of the disease.
Authors and Affiliations
V. Zaichick, S. Zaichick
Keywords
Related Articles
- EP ID EP347454
- DOI 10.9734/BJMMR/2015/17572
- Views 69
- Downloads 0
Short Term Rehospitalisation or Death and Determinants after Acute Heart Failure Admission in a Cohort of African Patients in Port Harcourt, Southern Nigeria
Background: Heart failure [HF] is a major health burden globally and contributes significantly to morbidity and mortality related to cardiovascular disease. The aim was to determine the outcome and factors that determine...
A Pilot, Randomized Sham Control Trial of Autologous Bone Marrow Derived Mononuclear Cells in Acute Ischemic Central Retinal Vein Occlusion
In this pilot, sham controlled randomized control trial (RCT) in patients with ischemic central retinal vein occlusion (CRVO), we studied the safety and efficacy of intravitreal injection of autologous bone marrow derive...
Circulating Dendritic Cells with their Dual Function are the Link Connecting Lymphatic Tissue and Brain
Aims: The objective of the paper is to reveal the sources in which the data about the main characteristics of the DCs have been shown and prove the theses of the “Theory of Duality of Protective Systems” (TDPS) formulate...
Relationship between the Anterior Fontanel Size and Occipito-frontal Circumference
Aims: To determine the relationship between Anterior Fontanel size (AF) and the Occipito-frontal circumference (OFC). Study Design: A cross sectional and analytical study of Nigerian newborns and infants. Place and Dur...
New Insight into the Mechanisms of the Anti-hyperglycemic Action of Metformin
Although metformin is currently one of the most frequently prescribed drugs for the treatment of type 2 diabetes, the precise mechanism of its molecular action is not fully understood. Metformin induces mild and transien...