DIFFERENTIAL SCANNING CALORIMETRY ANALYSIS, EQUILIBRIUM SOLUTION AND LIPID-WATER PARTITION COEFFICIENT OF O-19, A PROMISING PRODRUG CANDIDATE OF O-DESMETHYLVENLAFAXINE
Journal Title: Topics in Chemical & Material Engineering (TCME) - Year 2018, Vol 1, Issue 1
Abstract
Compound O-19 is a promising prodrug candidate of O-desmethylvenlafaxine (ODV) with excellent oral bioavailability and improved brain uptake. In present investigation, with the aim to gain the information on druggability of O-19, the DSC analysis and physicochemical properties including solubility (S), lipid/water partition coefficient (Log P) coupled with solid state stability evaluation were performed and compared with ODV. Results indicated that O-19 showed unique double peaks associated with the crystal transition during differential scanning calorimeter (DSC) processing as well as excellent stable properties during storage in room temperature. Its solubility and Log P exhibited similar trends towards ODV and mainly influenced by the countered pH environment. Herein, this work would be helpful for the further development of O-19 as a novel antidepressant drug
Authors and Affiliations
Zihao Zhang, Guiyong Wang, Zhongyu Zhang, Yang Zhang
Keywords
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- EP ID EP414503
- DOI 10.26480/icnmim.01.2018.222.225
- Views 52
- Downloads 0
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